Osaka Expo 2025

Introduction

The human brain relies on complex electrical communication between billions of neurons. To better understand these processes and develop treatments for neurological diseases, researchers grow brain organoids—3D mini brain-like structures derived from human stem cells. While being useful, individual organoids are relatively simple and limited in network complexity.

To address this, a technique developed at the Ikeuchi lab is use that connects multiple organoids using microfluidic chips, enabling the formation of axon bundles between them. These connected organoids, or "connectoids," better replicate the brain’s network architecture. To analyze the neural activity within these networks, we use MaxWell Biosystems’ MaxOne High-Density Microelectrode Arrays (HD-MEAs). This technology enables high-resolution recording and stimulation of neuronal signals, allowing detailed study of brain-like communication.

By combining connectoid systems with HD-MEA technology, we can investigate brain function, model diseases, and test treatments in a controlled lab setting—advancing the development of “neural networks on a chip” through international and interdisciplinary collaboration.

Exhibition (June 12 - August 12)

In collaboration with MaxWell Biosystems the project "Brain Networks on a Chip" was exhibited at the Swiss pavilion at the Osaka Expo 2025 from June 12 - August 12. The exhibit featured 18 connected organoids made of real cells grown on a MaxWell Biosystems chip. Visitors could see the organoids positioned on the chip through a microscope, while a monitor displayed the electrical signal traces recorded from these neural networks on a small disply next to it. Additionally, an enlarged mockup of the connected organoids on a chip was presented, equipped with LEDs inside each organoid that lit up to mimic their electrical activity, providing a vivid and interactive visualization of how these living brain networks communicate.

More about the Exhibition

Pictures of the exhibit at the Swiss pavilion

Event (August 4th)

On August 4th, we organized the event "From Petri Dish to Processor: Exploring the Future of Computing" at the Swiss pavilion, an event that brought together leading experts from Switzerland and Japan to explore how lab-grown neural networks—living neurons cultured outside the body—could transform brain research and lead to new forms of biological computing.

The event highlighted key advancements in tissue engineering and microelectrode array (MEA) technology, which together allow researchers to grow, monitor, and manipulate neural activity. Two panel discussions explored the scientific and technological potential of these neural systems, as well as the importance of interdisciplinary and international collaboration. The first panel focused on how lab-grown neurons can deepen our understanding of brain function and inspire new computing models. The second showcased Swiss–Japanese partnerships that combine neuroscience, engineering, and data science to drive innovation in this emerging field.

The event offered a glimpse into a future where biology and computing converge, opening new possibilities for medicine, research, and technology.